Conversations with the founders, physicians, investors and researchers building healthcare technology, hosted by a practicing oncologist. Each episode below comes with a short written summary so you can find the ones worth your time.
3 hr 58 min
The full story of OpenEvidence, from founder Daniel Nadler selling Kensho to S&P Global for $550 million to building a clinical decision support tool that now handles about 358,000 physician queries a day. Covers the technical architecture, the Mayo Clinic partnership, the USMLE 100% score debate, the funding rounds from Series A through D, and the move into AI scribing and DeepConsult.
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4 hr 2 min
A long-form history of the "LinkedIn for Doctors." Follows Jeff Tangney from Epocrates, the first medical app on the iPhone, to Doximity's reach into roughly 80% of US physicians. Explains why Sermo and Osmosis stalled, how the business model keeps physicians on side, the Curative, Amion and Pathway acquisitions, and the launch of Doximity GPT amid the AI scribe wars.
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35 min
Dr. Rishi Khakhkhar, Chief Medical Officer at Counsel Health, on chat-based, physician-supervised medical AI. Walks through the patient journey from AI intake to a physician, asynchronous versus near-synchronous care, emergency escalation protocols, and the "clinician cockpit" tools built for doctors. Counsel raised a $35M Series A led by Andreessen Horowitz and Google Ventures.
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38 min
Rishab Veldur and Kevin Volkema of Auvi Labs on dialysis access failure, which hits about 40% of dialysis patients in their first year. They describe Beacon, a wearable ultrasound patch used 10 minutes a day to catch early warning signs, and the path from a university capstone to a 20-patient pilot. Also covers finding clinical pilots, networking as a founder, and the risks of scaling.
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38 min
Dr. Amit Phull, Chief Physician Experience Officer at Doximity, on building AI tools by physicians, for physicians. Topics include Doximity GPT and HIPAA compliance, the Pathway acquisition, the privacy-first AI scribe, why he keeps practicing emergency medicine, and lessons from products that failed.
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44 min
Dr. Eve Cunningham, Chief Medical Officer at Cadence, on remote patient monitoring for more than 70,000 patients across 20 health systems. Covers continuous versus episodic care, how a practicing OB-GYN moved into healthtech leadership, medication titration insights, Medicare monitoring billing codes, and results like 18% fewer hospitalizations.
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23 min
Malke Asaad, a plastic surgery resident, on building Rank RX, an LLM platform that screens 1,000 to 2,000 residency applications in minutes. Covers why cutoff-based filtering is unfair, how program-specific scoring works, assembling a tech team without a coding background, and checking that a startup idea solves a problem people will pay for.
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25 min
Sahil, co-founder of Otoset, on how an FDA 510(k)-cleared ear cleaning device led to over a billion social media views and a pivot to a direct-to-consumer ear care network. Covers moving from partner clinics to company-owned locations, a $99 first treatment, organic and influencer marketing, and what FDA clearance means for credibility.
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36 min
A Stanford biomedical data science PhD researcher explains why 95% accuracy on medical exams does not predict clinical performance. When GPT-4, Claude and DeepSeek were tested on modified medical questions, accuracy dropped by up to 40%. Also covers a 35-dataset benchmark of real clinical tasks, why models struggle when "none of the above" is correct, and how doctors can use AI as a co-pilot.
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6 min
How an oncologist who has taken 16+ medical exams uses ChatGPT and image generators to build visual mnemonics for drug names. Covers asking for text-based memory aids before images, examples like pexidartinib and vimseltinib for tenosynovial giant cell tumor, topotecan versus irinotecan metabolism, and moving the results into Anki flashcards.
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24 min
Charlene Wang, CEO of Ember, on fixing healthcare revenue integrity with AI. Ember helps hospitals recover 51% of initially denied claims, adding over $60,000 a month in revenue for clients. Covers ambient listening, how the product works, the Y Combinator experience, building the right team, and the value of focusing on one problem.
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5 min
A step-by-step tutorial on making publication-ready scientific illustrations with ChatGPT, Gemini and free Canva. Shows how to generate cancer cells, CD8 T-cells, antibodies and receptors, fix inaccurate details through prompting, and combine the pieces into a figure.
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5 min
Three prompt techniques for getting better results from ChatGPT, Claude and Gemini: persona prompts, asking AI to write better prompts for you, and text expander tools that save typing. Includes examples from medical practice.
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26 min
University of Washington researcher Sihan explains TrajSurv, a model that predicts ICU survival from the first 36 hours of EHR data. It turns noisy, irregular time series into interpretable trajectories, handles missing data without heavy imputation, and was validated on MIMIC-III and eICU with a C-index around 0.80.
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3 min
A short course overview for physicians: LLM foundations, prompt engineering, AI in clinical practice and patient care, research methods, teaching with AI, critically evaluating AI tools, and privacy and ethics.
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39 min
Dimitri, founder and CEO of Y Combinator-backed WorkDone Health, on building the "Grammarly for medical records." The platform automates chart review, compliance checks and billing validation in real time, aimed at the $70 billion in denied claims and $55 billion in lawsuits tied to documentation errors each year. Also covers why CFOs feel the pain first and lessons from Y Combinator.
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22 min
Chuck Feerick, founder and CEO of Latitude Health, on prior authorization and utilization management. He explains how a personal experience in his early 20s led him to use AI to reduce administrative burden for health plans and speed patient access to treatment, drawing on a background in health plan operations, venture capital and startups.
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7 min
Persona prompting, zero-shot versus few-shot prompts for case summaries and clinical trials, chain-of-thought prompting for complex scenarios, and flipped-interaction prompts, applied to clinical and research work in ChatGPT and Gemini.
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15 min
A physician's guide to choosing between ChatGPT, Gemini, Claude and medical tools like OpenEvidence and Doximity GPT. Covers how LLMs work, training data, internet access, context windows, free versus paid tiers, and privacy and HIPAA concerns.
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5 min
The opening video of the AI for Physicians series. Explains AI, machine learning and deep learning with clinical analogies, supervised versus unsupervised versus reinforcement learning, and where generative AI like ChatGPT and NotebookLM fits.
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26 min
Tikran Bdoyan, co-founder of SimAI, on virtual patients for medical education. SimCare AI reduces training bottlenecks, speeds up student evaluation and feedback, and supports medical schools, residency programs and CME. Also covers its Y Combinator journey and fundraising in healthcare and edtech.
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29 min
A breakdown of Microsoft's AI Diagnostic Orchestrator, a multi-agent system built on GPT-4, Gemini 2.5 and Claude Opus that diagnosed rare NEJM case challenges four times more accurately than 21 generalist physicians. Explains why USMLE benchmarks fall short, how the gatekeeper and judge agents work, the accuracy-versus-cost results, and the limitations.
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39 min
Jeff Fidelman, a Harvard-trained banker, ex-Morgan Stanley and former venture partner, on raising capital as a HealthTech or MedTech founder. Covers common mistakes, structuring the deck, model and valuation, SAFEs versus convertible notes, and using AI to cut MVP time and fundraising cost.
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31 min
Ian Shakil, founder of Augmedix, and Dr. Bill Mitchell, a practicing oncologist who uses its ambient AI scribe, on how ambient AI saves hours a day and reduces burnout. Covers the journey of building Augmedix and its human-in-the-loop approach.
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29 min
Marco, biomedical engineer and founder of Rook, on a platform that integrates data from 300+ wearable devices for clinicians and developers. Covers data standardization, HIPAA, GDPR and SOC 2 compliance, and how AI is reshaping MedTech.
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9 min
Highlights from ViVE 2025 in Nashville: AI scribes, virtual care and cybersecurity, plus tips for networking with founders, investors and fellow clinicians at a healthcare technology conference.
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27 min
Ankit Jain, founder of Infinitus Systems and former Google engineering director, on voice AI for healthcare administration. Covers short-staffed teams, critical patient calls, and the challenges and wins of launching a health tech startup.
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26 min
Caroline Zhang, founder and CEO of Knowtex, on using generative AI to streamline medical documentation and billing. Her path runs from medical scribe to Stanford AI expert, and the conversation returns to the importance of staying user-focused.
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28 min
Dr. Andre Esteva, CEO of Artera, on AI-driven tests that guide prostate cancer treatment, validated in clinical trials. Covers how Artera secured insurance reimbursement, the biggest hurdles in HealthTech, and fitting into clinical workflows.
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16 min
How to use ChatGPT and Google Gemini as hands-free voice tutors. Covers setting up voice mode, managing token limits, multimodal learning, and using AI for everything from studying medical topics to cooking.
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39 min
Huzaifa Sial, founder of Helpcare AI, on AI-powered care coordination. Covers automating administrative work, real-time patient outreach and engagement, the promise of preventive medicine, and using Y Combinator to accelerate a HealthTech startup.
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7 min
Strategies for learning with AI, with a focus on writing good questions and using AI platforms for personalized study, interactive feedback and automated assessment.
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35 min
Alan Lucas, CEO of Navigation Sciences, on soft-tissue navigation for lung cancer and other tumors, and why precise surgical margins matter. Covers FDA pathways, fundraising, and collaboration among startups, researchers and policymakers.
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7 min
Practical ways to study with AI: summarizing and organizing complex topics, custom prompts and templates, efficient research and note-taking, and workflow tips with quick wins.
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7 min
A step-by-step approach to building an AI-assisted study plan: set clear goals, choose the right tools, organize your schedule, and use instant feedback and interactive resources.
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24 min
Why customization and context make or break an AI scribe, using Heidi as the example. Covers templates, context windows and LLM tuning for better note organization and less physician burden.
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14 min
How NotebookLM and ChatGPT turn dense clinical material into accessible lessons, interactive Q&A and audio content, with examples from oncology, research and data analysis.
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34 min
Eirini Schlosser, founder and CEO of Dyania Health, on using AI and natural language processing to automate manual chart review. Covers how it saves clinicians hours and speeds up clinical trial recruitment.
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56 min
Dr. Michael Lesh and Dr. Mandar Karhade, founders of Quench, on using generative AI to organize and review medical records for the medical-legal field, work that is slow and tedious for clinicians and attorneys alike.
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18 min
How healthcare payment changed over time: fee-for-service and its focus on volume, HMOs in the 1970s, DRGs in the 1980s, standardized coding, and the move toward value-based care.
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15 min
A primer for founders and anyone entering healthcare: how fee-for-service works, what CPT and ICD codes do, and why the model rewards procedures over patient outcomes.
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42 min
Matthew, founder of Diabetic U, on an app that pulls data from over 300 devices, including Dexcom G6 and G7, into personalized meal and exercise plans. Covers his personal experience with diabetes, assembling a clinical advisory board, and go-to-market strategy.
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18 min
What whole-body MRI is, how it compares with CT and X-ray, its potential for early cancer detection and prevention, and whether it can pick up conditions beyond cancer such as rheumatoid arthritis and heart disease.
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18 min
A walkthrough of PathwayMD, an AI clinical decision support tool that gives evidence-based answers with direct references to guidelines. Looks at the interface, medical calculators and study updates.
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45 min
Dr. Kelly, CEO of Heidi Health, on how AI scribes are changing documentation. Covers Heidi's customization features, where AI scribes are headed, and the journey from idea to execution.
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30 min
Chris Green, Chief Business Officer at Endiatx, on PillBot and gastric cancer. Covers nine months of progress, including human trials in New Zealand, and relationships with clinical advisors at the Mayo Clinic.
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30 min
A PitchBook senior financial analyst reviews Q1 2024 HealthTech and MedTech trends: notable VC deals, mergers and acquisitions, AI in diagnostics, whole-body scans, cardiac arrest prevention, and companies like Health.io and Paige.
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54 min
Dr. Zeev Neuwirth, a healthcare executive and author with 15 years of clinical practice and 15 more in healthcare leadership, on why healthcare needs disruptive change and a more human-centered system.
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40 min
Spencer Honeyman, Chief Commercial Officer at a vertical AI company, on using AI to improve patient engagement, retention and outcomes in health plans, health systems and care management programs. Includes customer case studies plus sales, marketing and hiring advice.
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41 min
Dr. Abramoff, a pioneer in medical AI, on the current state, challenges and future of AI in healthcare. Covers the need for continuous updates and funding for AI systems and his recent review on adopting AI in value-based care settings.
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50 min
Amit Garg, a seed-stage digital health investor with two decades in Silicon Valley, on trends and opportunities, the role of physicians in shaping startups, how investors evaluate health tech ventures, and how AI is changing healthcare.
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44 min
Himanshu Misra, founder of Enlighten AI, on software for seizure monitoring and personalized epilepsy treatment. He shares the personal story, the loss of his son to epilepsy, that led him to build it.
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18 min
A look at a Stanford study on AI-generated draft replies to patient inbox messages. Explores how AI takes on repetitive administrative work inside the EHR so clinicians can save their energy for complex decisions, without losing the human touch.
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38 min
A conversation on healthcare's billion-dollar companies: the decline of late-stage funding for unicorns, the shift toward profitability and enterprise models, interest in digital therapeutics and telehealth, and consolidation in digital health.
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34 min
Justin Beals, CEO of Strike Graph, on the breaches at 23andMe and Change Healthcare, the UnitedHealth Group subsidiary where 6 terabytes of data were stolen. Covers how attackers got in, the fallout across the US healthcare system, and how to prevent the next one.
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17 min
How Claude 3, which is SOC 2 compliant, can help physicians: improving medical notes, communicating with other healthcare workers, brainstorming, building differential diagnoses and creating patient materials.
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25 min
A hands-on review of Heidi as a "digital intern" that writes notes, provider emails and patient handouts. Checks the website and security compliance (HIPAA, PIPEDA, GDPR) and puts the tool to the test.
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36 min
Justin Beals, CEO of Strike Graph, on why cybersecurity is a make-or-break issue for HealthTech startups. A single attack in healthcare can cost about $10.1 million, and standards like HIPAA and SOC 2 are expected.
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16 min
Two tools for finding medical literature, compared on an example case. Looks at the interface, how references are presented, reliability and comprehensiveness.
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45 min
AvoMD's point-of-care app for systematizing clinical decisions, aligned to the guidelines and protocols of the hospital or clinic, with risk calculators and real-time documentation.
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48 min
Keva Health, founded after the founders' daughter was diagnosed with asthma at age 3, on monitoring that goes beyond inhalers. Real-time feedback helps patients catch problems early and gives providers a view of how patients are doing.
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31 min
Leo Grady of Jona on using AI to decode the gut microbiome and turn fast-moving microbiome research into practical benefits for patients.
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27 min
A real-life test of Abridge with a standardized patient, evaluating the website, user interface, privacy features, accuracy and pricing.
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53 min
Peter Fasse, a patent attorney at Fish & Richardson, on why patents are one of a startup's most valuable assets and how patent prosecution works across biotech, healthcare and medical devices.
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25 min
A real-time test of Nabla with a standardized patient, covering the interface, pricing, security and privacy, and a close read of the notes it generates.
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51 min
How tremor affects writing, eating and using a phone, and how SteadiWear's stabilization technology aims to help people living with it.
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51 min
DNA nanobots as a precision approach to cancer treatment that could reduce the need for harsh chemotherapy and radiation, with a look at the companies working in the space.
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50 min
How AI is addressing inconsistent pathology reports and disagreement between pathologists in cancer diagnosis, with a look at Paige's work in computational digital diagnostics.
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25 min
The second half of the conversation with Prof. Shahram Yousefi on building Mesh AI and its approach to clinician scheduling and burnout.
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31 min
Prof. Shahram Yousefi, CEO of Mesh AI, on one-click scheduling for healthcare providers, a tool built to ease clinician burnout by giving clinicians more control over their schedules.
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45 min
Dr. Karim Hanna, founding Program Director of the USF Tampa General Hospital Family Medicine Residency and author of the AI + MedEd newsletter, on bringing data and AI into medical education and practice.
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1 hr 3 min
Talal Ali Ahmad, CEO of Predictive Healthcare, on a platform that connects physicians and patients after discharge. AI flags which abnormal results matter so inboxes do not overflow, while patients report wound healing, vitals and daily activity.
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41 min
Torrey Smith shares advice for health tech founders, from navigating FDA regulations to building a dynamic team, plus the challenges he faced and what he learned.
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50 min
Torrey Smith of Endiatx on PillBot, a pill-sized robot that works as a virtual endoscope for remote diagnosis and treatment in the GI tract, and how the company got started.
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46 min
Dr. Alberto Rodriguez-Navarro, a minimally invasive surgeon with over a decade of experience, on magnetic approaches to surgery and a research-driven push for better outcomes and resource use.
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1 hr 6 min
FDA attorney Katherine Giannamore on how the FDA regulates medical devices, the pathways startups can take to market, and the common pitfalls and myths that trip up founders.
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1 hr 2 min
Dr. Worthley, a corresponding author of a synthetic biology paper, on engineered bacteria that can detect colon cancer early and what that could mean for screening.
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39 min
Dr. Hu, an engineer in Professor Sheng Xu's group at UC San Diego, on a wearable ultrasound device that assesses cardiac function in real time, overcoming the bulk and time cost of traditional cardiac imaging.
Watch on YouTubeSub-three-minute clips and Shorts are left out. Everything, including those, is on the Delta: HealthTech Innovators channel. Guest titles and companies are as they were at the time of recording.